mTOR in Viral Hepatitis and Hepatocellular Carcinoma: Function and Treatment
As the fifth most common cancer in men and the eighth most common cancer in women, hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, with standard chemotherapy and...
View ArticleMicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and...
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer, with dismal outcomes and an increasing incidence worldwide. Hepatocarcinogenesis is a multistep process that progresses...
View ArticleTransarterial Chemoembolization for the Treatment of Advanced Hepatocellular...
Transarterial chemoembolization (TACE) could achieve a better survival benefit than conservative treatment for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). In this...
View ArticleTherapeutic Potential of MicroRNA: A New Target to Treat Intrahepatic Portal...
Intrahepatic portal hypertension accounts for most of the morbidity and mortality encountered in patients with liver cirrhosis, due to increased portal inflow and intrahepatic vascular resistance. Most...
View ArticleMelatonin in the Regulation of Liver Steatosis following Prenatal...
Nonalcoholic fatty liver disease patients are characterized by hepatic steatosis. Prenatal glucocorticoid overexposure can result in steatosis. In this study, we aimed to determine the mechanism and...
View ArticleEndocannabinoid Receptors Gene Expression in Morbidly Obese Women with...
Background. Recent reports suggest a role for the endocannabinoid system in the pathology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship between...
View ArticleInvolvement of DNA Damage Response Pathways in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) has been known as one of the most lethal human malignancies, due to the difficulty of early detection, chemoresistance, and radioresistance, and is characterized by...
View ArticleSynergistic Effect of MiR-146a Mimic and Cetuximab on Hepatocellular...
Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent...
View ArticleMultidisciplinary Management of Hepatocellular Carcinoma in Clinical Practice
Background. Hepatocellular carcinoma (HCC) patients require different treatment strategies according to disease extension, liver function, and patient’s fitness. We evaluated HCC multidisciplinary...
View ArticleAdhesion of Pancreatic Cancer Cells in a Liver-Microvasculature Mimicking...
Organ-specific characteristic of endothelial cells (ECs) is crucial for specific adhesion of cancer cells to ECs, which is a key factor in the formation of organ-specific metastasis. In this study, we...
View ArticleHepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against...
The hepatoprotective and antioxidant activity of Bauhinia hookeri ethanol extract (BHE) against CCl4-induced liver injury was investigated in mice. BHE was administered (500 and 1000 mg/kg/day) along...
View ArticleSupplementation of T3 Recovers Hypothyroid Rat Liver Cells from Oxidatively...
Hypothyroidism is a growing medical concern. There are conflicting reports regarding the mechanism of oxidative stress in hypothyroidism. Mitochondrial oxidative stress is pivotal to thyroid...
View ArticleIn Vitro Inhibition of Hepatitis C Virus by Antisense Oligonucleotides in...
Aim. To assess the efficiency of phosphorothioate antisense oligodeoxynucleotide 1 (S-ODN1) on HCV translation inhibition in PBMC compared to hepatoma cells in vitro for the first time. Materials and...
View ArticleAntioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts,...
Delonix elata L. (Ceasalpinaceae), is widely used by the traditional medical practitioners of Karnataka, India, to cure jaundice, and bronchial and rheumatic problems. The objective of this study was...
View ArticleOn the Mechanism(s) of Membrane Permeability Transition in Liver Mitochondria...
Previously we have shown that opening of the mitochondrial permeability transition pore in its low conductance state is the case in hepatocytes of the Baltic lamprey (Lampetra fluviatilis L.) during...
View ArticleCapitalizing on the Autophagic Response for Treatment of Liver Disease Caused...
Alpha-1-antitrypsin deficiency (ATD) is one of the most common genetic causes of liver disease and is a prototype of liver diseases caused by the pathologic accumulation of aggregated mutant...
View ArticleIntegrated Autofluorescence Characterization of a Modified-Diet Liver Model...
Oxidative stress in fatty livers is mainly generated by impaired mitochondrial β-oxidation, inducing tissue damages and disease progression. Under suitable excitation, light liver endogenous...
View ArticleCrude Extracts from Lycium barbarum Suppress SREBP-1c Expression and Prevent...
Lycium barbarum polysaccharide (LBP) is well known in traditional Chinese herbal medicine that, has beneficial effects. Previous study reported that LBP reduced blood glucose and serum lipids. However,...
View ArticleLobe-Specific Heterogeneity in Asymmetric Dimethylarginine and Matrix...
We investigated the effects of obstructive cholestasis in different hepatic lobes by evaluating asymmetric dimethylarginine (ADMA) (a nitric oxide synthase inhibitor), protein methyltransferase (PRMT)...
View ArticleDiagnosis System for Hepatocellular Carcinoma Based on Fractal Dimension of...
Background and Aims. Hepatocellular carcinoma (HCC) remains a leading cause of death by cancer worldwide. Computerized diagnosis systems relying on novel imaging markers gained significant importance...
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