Risk Factors for Hepatocellular Carcinoma Recurrence and Survival after Liver...
Purpose. We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related...
View ArticleAmarogentin Inhibits Liver Cancer Cell Angiogenesis after Insufficient...
Background. Whether and how amarogentin suppresses the angiogenesis effect in liver cancer cells after insufficient radiofrequency ablation (iRFA) are still poorly studied. Methods. The number of liver...
View ArticleAssociation between Circulating Growth Differentiation Factor 15 and...
Primary biliary cholangitis (PBC) is a common condition that usually shows a progressive course towards cirrhosis without adequate treatment. Growth differentiation factor 15 (GDF15) plays multiple...
View ArticleA Nomogram Model Based on Noninvasive Bioindicators to Predict 3-Year Risk of...
The purpose of this study is to establish and validate an accurate and personalized nonalcoholic fatty liver disease (NAFLD) prediction model based on the nonobese population in China. This study is a...
View ArticleProtective Effects of Quercetin on Livers from Mice Exposed to Long-Term...
Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant...
View ArticleSpleen Stiffness Predicts Survival after Transjugular Intrahepatic...
Objectives. Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for portal hypertensive complications. Little is known about the ability of spleen stiffness (SS) for...
View ArticleProtective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study
Background. Treating nonalcoholic fatty liver disease (NAFLD) is considered one of the public health priorities in the past decade. So far, probiotics have represented promising results in controlling...
View ArticleAPOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic...
Single-nucleotide polymorphisms (SNPs) of apolipoprotein C3 (APOC3) play important role in lipid metabolism, and dyslipidemia underlies nonalcoholic fatty liver disease (NAFLD). But the correlation of...
View ArticleInfluence of Alanine Transaminase Levels on Alpha-Fetoprotein for Predicting...
Purpose. To investigate the influence of alanine transaminase (ALT) on the accuracy of alpha-fetoprotein (AFP) for detecting hepatocellular carcinoma (HCC).Methods. This retrospective study recruited...
View ArticleProtective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in...
Sepsis increases the risk of the liver injury development. According to the research works, coenzyme Q10 exhibits hepatoprotective properties in vivo as well as in vitro. Current work aimed at...
View ArticleNeutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict...
Background and Aims. Alcohol-associated liver disease is exhibiting an increasing disease burden. In terms of pathogenesis, inflammation is closely related to alcohol-induced liver injury. The...
View ArticleOral Health-Related Quality of Life in Chronic Liver Failure Patients...
Background. Oro-dental diseases are prevalent in chronic liver failure (CLF) patients. The aim of this study was to evaluate the quality of life associated with oral health in candidates for liver...
View ArticleKIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with...
Background. Hepatocellular carcinoma (HCC) lacks effective treatments and has a poor prognosis. Therefore it is needed to develop more effective drug targets. Kinesin family member 11 (KIF11) has been...
View ArticleNatural Killer T Cells in Various Mouse Models of Hepatitis
Natural killer T (NKT) cells are a key component of innate immunity. Importantly, a growing body of evidence indicates that NKT cells play an integral role in various acute and chronic liver injuries....
View ArticleRoles of Bile-Derived Exosomes in Hepatobiliary Disease
Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as...
View ArticleThe Characteristics of Natural Killer Cells in Chronic Hepatitis B Patients...
Background. To explore the role of natural killer (NK) cells in the process of hepatitis B virus (HBV) clearance and whether their phenotype is related to antiviral treatment outcome in chronic...
View ArticleMicroarray Data Mining and Preliminary Bioinformatics Analysis of Hepatitis D...
Several studies have demonstrated that chronic hepatitis delta virus (HDV) infection is associated with a worsening of hepatitis B virus (HBV) infection and increased risk of hepatocellular carcinoma...
View ArticleSerum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated...
Introduction and Aims. Bile acids play an essential role in the progression of nonalcoholic fatty liver disease (NAFLD). This study was aimed at investigating the association of the serum glycocholic...
View ArticleInterferon-Induced Transmembrane Protein 3 Expression Upregulation Is...
Purpose. Interferon-induced transmembrane protein 3 (IFITM3) is a key signaling molecule regulating cell growth in some tumors, but its function and mechanism in hepatocellular carcinoma (HCC) remain...
View ArticleThe Combination of Shear Wave Elastography and Platelet Counts Can...
Background. Baveno VI criteria, based on liver stiffness (LS) measured by transient elastography and platelet counts (PLT), have been proposed to avoid unnecessary endoscopy screening for high-risk...
View ArticleA Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin...
Objective. This study is aimed at investigating the enriched functions of polymeric immunoglobulin receptor (PIGR) and its correlations with liver fibrosis stage. Methods. PIGR mRNA expression in...
View ArticleSpleen Stiffness Performance in the Noninvasive Assessment of...
Objectives. To investigate the performance of spleen stiffness (SS) by using two-dimensional shear-wave elastography (2D-SWE) for assessing the severity of gastroesophageal varices (GEVs) after...
View ArticlePrevalence and Associated Factors of Portopulmonary Hypertension in Patients...
Background and Aims. There are few studies on the prevalence and clinical characteristics of portopulmonary hypertension (POPH) in patients with portal hypertension. In addition, invasive right heart...
View ArticleIncrease in Free Hepatic Venous Pressure Response to Beta-Blockers Predicts...
Background and Aims. Nonselective beta-blockers (NSBBs) are the main drug to prevent portal hypertension. It could alter free hepatic venous pressure (FHVP); however, the significance is unknown. This...
View ArticleMechanistic Investigation on the Regulation of FABP1 by the IL-6/miR-603...
Background. Abnormal lipid metabolism is closely associated with the invasiveness and metastasis of cancer. Fatty acid-binding proteins (FABPs) play essential roles in lipid metabolism, and miRNAs can...
View ArticleIntegrated Analysis of Long Noncoding RNA Expression Profiles in...
People infected with chronic hepatitis B virus (HBV) might progress to acute-on-chronic liver failure (ACLF) with a high fatality rate. Long noncoding RNAs (lncRNAs) are involved in human diseases, but...
View ArticleDownregulation of snoRNA SNORA52 and Its Clinical Significance in...
Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic...
View ArticleLiver Enzymes and Their Association with Some Cardiometabolic Diseases:...
Objective. According to reports, liver enzymes might play a role in the incidence and development of cardiometabolic diseases such as metabolic syndrome (MetS), hypertension (HTN), and cardiovascular...
View ArticleAntitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular...
Background and Aim. Although a strong antitumor effect of lenvatinib has been noted for patients with unresectable hepatocellular carcinoma (HCC), its efficacy requires improvement. It is imperative to...
View ArticleAssociation of Low High-Density Lipoprotein Cholesterol Levels with Poor...
Background. Lipid levels become decreased in cirrhotic patients and are correlated with disease severity. In the present study, we investigated the impact of serum high-density lipoprotein cholesterol...
View ArticlePicroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury...
Picroside II is an important ingredient agent in Traditional Chinese medicine and hoped to reduce hepatocellular injury caused by severe acute pancreatitis (SAP). An SAP-induced hepatocellular injury...
View ArticleEffects of Preoperative Oral Carbohydrate on Cirrhotic Patients under...
Preoperative fasting causes significant perioperative discomfort in patients. Preoperative oral carbohydrate (POC) is an important element of the enhanced recovery after surgery protocol, but its...
View ArticleLycopene Ameliorates Liver Inflammation and Redox Status in Mice Exposed to...
Cigarette smoke (CS) is the major cause of preventable death worldwide, and it can also cause damage to extrapulmonary organs, such as the liver, mainly due the generation of reactive oxygen species...
View ArticleTreg/Th17 Cell Balance in Patients with Hepatitis B Virus-Related...
Background. T-helper 17 (Th17) and CD4+CD25+ T-regulatory (Treg) cells play important roles in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This study is...
View ArticleEffects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules...
The aim of the present study was to investigate the effects and mechanism of oxymatrine (OMT) combined with compound yinchen granules (CYG) on the apoptosis of hepatocytes through the Akt/FoxO3a/Bim...
View ArticleMultiple Intestinal Bacteria Associated with the Better Protective Effect of...
Bifidobacterium pseudocatenulatum LI09 could protect rats from D-galactosamine- (D-GalN-) induced liver injury. However, individual difference in the protective effects of LI09 on the liver injury...
View ArticleIdentification of MAD2L1 as a Potential Biomarker in Hepatocellular Carcinoma...
Background. Hepatocellular carcinoma (HCC) is widely acknowledged as a malignant tumor with rapid progression, high recurrence rate, and poor prognosis. At present, there is a paucity of reliable...
View ArticleDiagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A...
Background. Serum chitinase-3-like protein 1 (CHI3L1) is a promising marker for diagnosing liver fibrosis. This meta-analysis was carried out to assess the diagnostic performance of serum CHI3L1 for...
View ArticleSilencing the ADAM9 Gene through CRISPR/Cas9 Protects Mice from...
Alcoholic liver injury is a major global public health concern at present. The ADAM9 gene plays a crucial role in the occurrence and development of various liver diseases, but its role in acute...
View ArticleIntervention of Shugan Xiaozhi Decoction on Nonalcoholic Fatty Liver Disease...
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with an increasing incidence rate but few therapies. Shugan Xiaozhi decoction (SX) has demonstrated beneficial effects in treating...
View ArticleAntiviral Therapy for Prevention of Perinatal Hepatitis B Virus Transmission...
Background: Currently, there are few studies on the effect of prophylactic anti-hepatitis B virus (HBV) therapy (AVT) for mother-to-child transmission during pregnancy on postpartum hepatitis flare...
View ArticleAdverse Effects of Bisphenol A on the Liver and Its Underlying Mechanisms:...
BPA is a known endocrine-disrupting agent that is capable of binding to the estrogen receptor and has exhibited adverse effects in many laboratory animal and in vitro studies. Moreover, it also been...
View ArticleOlmesartan Improves Hepatic Sinusoidal Remodeling in Mice with Carbon...
Aim. In mice with liver fibrosis produced by carbon tetrachloride (CCl4), the effects of olmesartan on intrahepatic angiogenesis and sinusoidal remodeling will be evaluated. Methods. By injecting CCl4...
View ArticleGRWR Correlates with the Metabolism of Tacrolimus after Pediatric Living...
Objectives. Tacrolimus is characterized by high pharmacokinetic variability in combination with a narrow therapeutic range. However, influence of donor CYP3A5 genotype and graft-to-recipient body...
View ArticleRosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by...
Background. Excessive acetaminophen (APAP) use can lead to acute liver injury (ALI) by inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with the peroxisome...
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