Natural Killer Cell Function and Dysfunction in Hepatitis C Virus Infection
Viruses must continually adapt against dynamic innate and adaptive responses of the host immune system to establish chronic infection. Only a small minority (~20%) of those exposed to hepatitis C virus...
View ArticleThe Effects of Apigenin on the Expression of Fas/FasL Apoptotic Pathway in...
Background. The aim of this experimental study was to investigate the role of apigenin in liver apoptosis, in an experimental model of hepatic ischemia-reperfusion in rats. Materials and Methods....
View ArticleHepatic Chemerin and Chemokine-Like Receptor 1 Expression in Patients with...
Introduction. Chemerin seems to be involved in pathogenesis of chronic hepatitis C (CHC). Hepatic expressions of chemerin and its receptor, chemokine receptor-like 1 (CMKLR1), in CHC have not been...
View ArticleEffects of Converting Tacrolimus Formulation from Twice-Daily to Once-Daily...
Typically, tacrolimus is administrated twice daily. Prolonged-release tacrolimus is the once-daily formulation and may be more convenient for patients. Experience with the administration of the...
View ArticleFactors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese...
Hepatitis C virus (HCV) infections spontaneously clear in approximately 15–45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the...
View ArticleAutophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential...
Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for...
View ArticleRuscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via...
The aim of the study was to investigate the protective effects of ruscogenin, a major steroid sapogenin in Ophiopogon japonicus, on experimental models of nonalcoholic steatohepatitis. HepG2 cells were...
View ArticleResveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury...
Resveratrol (Rev) can ameliorate cytotoxic chemotherapy-induced toxicity and oxidative stress. Arsenic trioxide (As2O3) is a known cytotoxic environmental toxicant and a potent chemotherapeutic agent....
View ArticleUncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy
Mitochondrial uncoupling protein 2 (UCP2) is suggested to have a role in the development of nonalcoholic steatohepatitis (NASH). However, the mechanism remains unclear. Autophagy is an important...
View ArticleAutophagy in HCV Infection: Keeping Fat and Inflammation at Bay
Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes,...
View ArticleChanges in ADMA/DDAH Pathway after Hepatic Ischemia/Reperfusion Injury in...
We investigated the effects of hepatic ischemia/reperfusion (I/R) injury on asymmetric dimethylarginine (ADMA, a nitric oxide synthase inhibitor), protein methyltransferase (PRMT) and dimethylarginine...
View ArticleLiver Autophagy in Anorexia Nervosa and Acute Liver Injury
Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is...
View ArticleTargeting the Raft-Associated Akt Signaling in Hepatocellular Carcinoma
Caveolin-1 and flotillin-1 are considered as markers of lipid rafts which can be regarded as sorting platforms for targeted transport of transmembrane proteins and are involved in fundamental cellular...
View ArticleEffects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C...
Objective. This study aimed to evaluate the efficacy and safety of silymarin on chronic hepatitis C virus- (HCV-) infected patients. Methods. Randomized controlled trials (RCTs) of silymarin in chronic...
View ArticleAutophagy: A Multifaceted Partner in Liver Fibrosis
Liver fibrosis is a common wound healing response to chronic liver injury of all causes, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide. Fibrosis results from...
View ArticleAutophagy and Non-Alcoholic Fatty Liver Disease
Autophagy, or cellular self-digestion, is a catabolic process that targets cell constituents including damaged organelles, unfolded proteins, and intracellular pathogens to lysosomes for degradation....
View ArticleChanging Interdigestive Migrating Motor Complex in Rats under Acute Liver Injury
Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and...
View ArticleEvaluation of the Effectiveness of Piper cubeba Extract in the Amelioration...
Background. Liver diseases still represent a major health burden worldwide. Moreover, medicinal plants have gained popularity in the treatment of several diseases including liver. Thus, the present...
View ArticleHepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver...
Protein phosphatase 2A (PP2A), a family of the major serine/threonine phosphatases in cells, regulates many aspects of physiological processes. However, isoform-specific substrates and the biological...
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