A Noninvasive Score Model for Prediction of NASH in Patients with Chronic...
Aims. To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD. Objective and Methods. 65 CHB patients with NAFLD were divided into NASH group (34 patients) and...
View ArticleIncreased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible...
Aim. ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis. This study aimed to find whether HBV infection altered ERp57 expression and...
View ArticleCarvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile...
Background. The sympathetic nervous system (SNS) is responsible for hepatic stellate cells (HSCs) activation and the accumulation of collagen that occurs in hepatic fibrogenesis. Carvedilol has been...
View ArticleNew Insights into the Epigenetics of Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate. This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and...
View ArticlePrevalence of Diabetes Type 2 in Hepatitis C Infected Patients in Kpk, Pakistan
Hepatitis C (HCV) and diabetes mellitus are the two main health concerns that cause devastating health and financial worries worldwide. It has been observed in the past that both diseases have a high...
View ArticleMagnetic Resonance Elastography Shear Wave Velocity Correlates with Liver...
Background. Portal hypertension, an elevation in the hepatic venous pressure gradient (HVPG), can be used to monitor disease progression and response to therapy in cirrhosis. Since obtaining HVPG...
View ArticleProtective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice
Chronic excessive alcohol consumption (more than 40–80 g/day for males and more than 20–40 g/day for females) could induce serious liver injury. In this study, effects of lemon juice on chronic...
View ArticleAbnormal Glucose Metabolism in Rheumatoid Arthritis
The incidence of abnormal glucose metabolism in patients with rheumatoid arthritis was considerably higher than the general population. The persistent systemic inflammatory state in rheumatoid...
View ArticleAdvances in the Diagnosis and Treatment of Acute Kidney Injury in Cirrhosis...
Liver cirrhosis is a common progressive and chronic clinical liver disease. Due to the strong compensation ability of the liver, no obvious symptoms develop in the early stage. However, multiple...
View ArticleDetection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in...
Background. In Egypt, the prevalence of chronic hepatitis C (CHC) infection is 13.8% of whole population and about 80% of the patients with hepatocellular carcinoma have underling hepatitis C. Aim....
View ArticleSurveillance Program for Diagnosis of HCC in Liver Cirrhosis: Role of...
International guidelines suggest ultrasound surveillance for hepatocellular carcinoma (HCC) early diagnosis in liver cirrhosis (LC) patients, but 40% of nodules <2 cm escape detection. We...
View ArticleFish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a...
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide. Recent studies have indicated that fish oil supplementation has benefits against NAFLD. Our...
View ArticlemiR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via...
Background. Although expression of miR-200s is aberrant in liver fibrosis, its role in liver fibrogenesis still remains unknown. Here, we investigated the role of miR-200c in the activation of human...
View ArticleAssessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal...
A significant unmet need exists for accurate, reproducible, noninvasive diagnostic tools to assess and monitor portal hypertension (PHT). We report the first use of quantitative MRI markers for the...
View ArticleCircular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory...
Circular RNAs (circRNAs) exhibit a wide range of physiological and pathological activities. To uncover their role in hepatic steatosis, we investigated the expression profile of circRNAs in HepG2-based...
View ArticlePlumbagin Alleviates Capillarization of Hepatic Sinusoids In Vitro by...
Critical roles for liver sinusoidal endothelial cells (LSECs) in liver fibrosis have been demonstrated, while little is known regarding the underlying molecular mechanisms of drugs delivered to the...
View ArticlePEGylated Curcumin Derivative Attenuates Hepatic Steatosis via...
Curcumin has the potential to cure dyslipidemia and nonalcoholic fatty liver disease (NAFLD). However, its therapeutic effects are curbed by poor bioavailability. Our previous work has shown that...
View ArticleHepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease
Many types of innate (natural killer cells, natural killer T cells, and Kupffer cells/macrophages) and adaptive (T cells and B cells) immune cells are enriched within the liver and function in liver...
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