Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver...
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in...
View ArticleDiagnosis and Management of Cirrhosis-Related Osteoporosis
Management of cirrhosis complications has greatly improved, increasing survival and quality of life of the patients. Despite that, some of these complications are still overlooked and scarcely treated,...
View ArticleTransitional Remodeling of the Hepatic Extracellular Matrix in...
Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well understood. The liver is the primary site of alcohol metabolism and is therefore the...
View ArticlePartial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced...
Hepatic infarcts or abscesses occur after hepatic artery interruption. We explored the mechanisms of hepatic deprivation-induced acute liver injury and determine whether partial portal vein...
View ArticleEvidence for a “Pathogenic Triumvirate” in Congenital Hepatic Fibrosis in...
Autosomal recessive polycystic kidney disease (ARPKD) is a severe monogenic disorder that occurs due to mutations in the PKHD1 gene. Congenital hepatic fibrosis (CHF) associated with ARPKD is...
View ArticlePathological Predictors of Shunt Stenosis and Hepatic Encephalopathy after...
Background. Transjugular intrahepatic portosystemic shunt (TIPS) is an artificial channel from the portal vein to the hepatic vein or vena cava for controlling portal vein hypertension. The major...
View ArticleiTRAQ-Based Proteomics Identification of Serum Biomarkers of Two Chronic...
Background. Chronic infection with hepatitis B virus (HBV) is a leading cause of cirrhosis and hepatocellular carcinoma. By traditional Chinese medicine (TCM) pattern classification, damp heat stasis...
View ArticleHuman Endogenous Retroviruses-K (HML-2) Expression Is Correlated with...
Background. The association between human endogenous retroviruses-K (HERV-K) (HML-2) and human disease, including a variety of cancers, has been indicated. However, the function of HERV-K (HML-2) in...
View ArticleHepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular...
Hepatocellular carcinoma (HCC) is a major public health concern and one of the leading causes of tumour-related deaths worldwide. Extensive evidence endorses that HCC is a multifactorial disease...
View ArticleCoronary Computed Tomography Angiography in Combination with Coronary Artery...
Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical...
View ArticleCellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver...
The emerging field of regenerative medicine offers innovative methods of cell therapy and tissue/organ engineering as a novel approach to liver disease treatment. The ultimate scientific foundation of...
View ArticleFavorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained...
Few studies have conducted follow-up investigations of the clinical course in HCV-related cirrhotic patients who achieved a sustained virological response (SVR) with pegylated interferon plus ribavirin...
View ArticleStellate Cell Activation and Imbalanced Expression of TGF-β1/TGF-β3 in Acute...
Objective. To study the pathogenic feature of liver injury, activation of hepatic stellate cells, and dynamic expression of TGF-β1/TGF-β3 to reveal their role in liver injury induced by ConA. Methods....
View ArticleGallstones in Patients with Chronic Liver Diseases
With prevalence of 10–20% in adults in developed countries, gallstone disease (GSD) is one of the most prevalent and costly gastrointestinal tract disorders in the world. In addition to gallstone...
View ArticleChenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and...
Aim. To investigate the effects of HS-1200 on liver tumorigenesis and liver function in a diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC) rat model. Methods. Rats were randomly...
View ArticleFunctional Roles and Therapeutic Applications of Exosomes in Hepatocellular...
Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to...
View ArticleSECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis
Liver fibrosis is a wound-healing response to chronic liver injury such as alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA-approved treatments. Liver fibrosis results in a...
View ArticleA Potential of sFasL in Preventing Gland Injury in Sjogren’s Syndrome
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL...
View ArticleDiagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in...
Liver biopsy still remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH), but with limitations. There is an urgent need to develop noninvasive tests that accurately distinguish...
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