Circulating MicroRNA-122 for the Diagnosis of Hepatocellular Carcinoma: A...
Background. Circulating microRNA-122 (miR-122) has been recognized as a marker of hepatocellular carcinoma (HCC). The current meta-analysis was performed to quantitatively evaluate the diagnostic...
View ArticleEffects of Nintedanib in an Animal Model of Liver Fibrosis
Systemic sclerosis can affect multiple internal organs, including the liver and lungs. Nintedanib, an antifibrotic approved for treatment of interstitial lung disease associated with systemic...
View ArticleA Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis
Background. This study aimed at presenting a novel method of developing a porcine model of portal vein thrombosis (PVT) in cirrhosis by intravenous administration of thrombin and insertion of a fibered...
View ArticleProtective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on...
Hepatic protective effects of Ligularia fischeri (LF) and Aronia melanocarpa (AM) against alcohol were investigated in vitro and in vivo test. LF, AM, and those composed mixing material (LF+AM) were...
View ArticleA Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of...
Nonalcoholic fatty liver disease, a type of metabolic syndrome, continues to rise globally. Currently, there is no approved drug for its treatment. Improving lifestyle and exercise can alleviate...
View ArticleDiagnostic and Prognostic Values of MANF Expression in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its prognosis is still poor. Mesencephalic astrocyte-derived neurotrophic factor (MANF) plays a key role in endoplasmic...
View ArticleThe Prevalence of NAFLD and Fibrosis in Bariatric Surgery Patients and the...
Background. Bariatric surgery patients have a higher prevalence of nonalcoholic fatty liver (NAFL) than the general population; however, its assessment and the accurate staging of fibrosis are often...
View ArticleEfficacy and Safety of Lamivudine or Telbivudine in Preventing...
Background. There are few large sample studies evaluating the safety and efficacy of lamivudine (LAM) or telbivudine (LdT) in preventing hepatitis B mother-to-child transmission (MTCT) in highly...
View ArticleHeme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic...
Background and Aim. Heme oxygenase-1 (HO-1) has been verified to play an important role in nonalcoholic steatohepatitis (NASH), but the mechanism remains unclear. In this study, we aimed to clarify...
View ArticleAbnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and...
Hepatotoxicity is historically the 3rd most common reason for drug withdrawal and toxicity-related discontinuation of treatment. This study was aimed at determining the incidence and the onset of...
View ArticleAnti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide...
Eucommia ulmoides polysaccharide (EUP) has been shown to have anti-inflammatory and antioxidant effects. However, the mechanism underlying these effects has rarely been reported, and whether EUP can...
View ArticleThe Risk of Acute Kidney Injury in Hepatitis B Virus-Related Acute on Chronic...
Aims. Tenofovir (TDF) is an antiviral drug with potential risk of kidney injury. The study is aimed at comparing the incidence of acute kidney injury (AKI) between TDF and entecavir (ETV) treatment in...
View ArticleRANKL Is Involved in Runx2-Triggered Hepatic Infiltration of Macrophages in...
Background. Receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) is significant in the activation of inflammation. Runt-related transcription factor 2 (Runx2) promotes the hepatic...
View ArticleA Novel Diagnostic Nomogram for Noninvasive Evaluating Liver Fibrosis in...
Objective. To establish a novel nomogram for diagnosing liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and verify the diagnostic performance of the established nomogram....
View ArticleDysregulation of Circulating FGF19 and Bile Acids in Primary Biliary...
Background. Primary biliary cholangitis-autoimmune hepatitis overlap syndrome (PBC-AIH OS), which exhibits features between autoimmune hepatitis and cholestasis, is a common condition and usually shows...
View ArticleGut Microbiota and Liver Fibrosis: One Potential Biomarker for Predicting...
Purpose. To investigate the relationship between gut microbiota and liver fibrosis and establish a microbiota biomarker for detecting and staging liver fibrosis. Methods. 131 Wistar rats were used in...
View ArticleCCNB2, TOP2A, and ASPM Reflect the Prognosis of Hepatocellular Carcinoma, as...
Background. Hepatocellular carcinoma (HCC) is characterized by increased mortality and poor prognosis. We aimed to identify potential prognostic markers by weighted gene coexpression network analysis...
View ArticleDownregulation of CRABP2 Inhibit the Tumorigenesis of Hepatocellular...
Cellular retinoic acid-binding protein 2 (CRABP2) binds retinoic acid (RA) in the cytoplasm and transports it into the nucleus, allowing for the regulation of specific downstream signal pathway....
View ArticleNo Benefit of Hemostatic Drugs on Acute Upper Gastrointestinal Bleeding in...
Background and Aims. Acute upper gastrointestinal bleeding (AUGIB) is one of the most life-threatening emergency conditions. Hemostatic drugs are often prescribed to control AUGIB in clinical practice...
View ArticleNo Association between Ischemic Stroke and Portal Vein Thrombosis in Liver...
Background and Aims. There seems to be a higher risk of ischemic stroke and portal vein thrombosis in liver cirrhosis. Both of them may be associated with hypercoagulability. We aim to explore the...
View Article