The Crosstalk between Hypoxia and Innate Immunity in the Development of...
Nonalcoholic fatty liver disease (NAFLD) has become a major health issue in western countries in parallel with the dramatic increase in the prevalence of obesity and all obesity related conditions,...
View ArticleComparative Study on the Cytoprotective Effects of Activated Protein C...
Activated protein C (APC) has cytoprotective effects on liver ischemia-reperfusion injury (IRI). However, it is unclear whether APC is beneficial in steatotic liver IRI. We compared the cytoprotective...
View ArticleAntioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis...
The aim of this study was to examine hepatoprotective effect of ethanolic extract of propolis (KPEt) from Kashmir Himalaya against isoniazid and rifampicin (INH-RIF) induced liver damage in rats....
View ArticlePharmacological Preconditioning by Adenosine A2a Receptor Stimulation:...
Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal...
View ArticlePPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver...
Ischemia-reperfusion injury (IRI) remains a frequent complication in surgery, especially in case of steatotic livers that present decreased tolerance towards IRI. Apart from its major role in...
View ArticleCurcumin Sensitizes Hepatocellular Carcinoma Cells to Radiation via...
The effects and possible underlying mechanism of curcumin combined with radiation in human hepatocellular carcinoma (HCC) cells in vitro were evaluated. The effects of curcumin, radiation, and...
View ArticleProtective Effect of Intravenous High Molecular Weight Polyethylene Glycol on...
Ischemia reperfusion injury (IRI) leads to significant tissue damage in liver surgery. Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proved their effectiveness against IRI....
View ArticleThe Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and...
Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this...
View ArticleMitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury
Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse...
View ArticleNovel Investigations of Flavonoids as Chemopreventive Agents for...
We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different...
View ArticleThe Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver...
Drug-induced liver injury (DILI) is a potentially fatal adverse event and the leading cause of acute liver failure in the US and in the majority of Europe. The liver can be affected directly, in a...
View ArticleFuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between...
Activation of hepatic stellate cells (HSCs) depending on epithelial-to-mesenchymal transition (EMT) reflects the key event of liver fibrosis. Contrastively, mesenchymal-to-epithelial transition (MET)...
View ArticleAdvanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1...
AGEs are a heterogeneous group of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and/or nucleic acids. AGEs have been shown to play a...
View ArticleEffect of Microenvironment on Differentiation of Human Umbilical Cord...
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) are considered to be an ideal cell source for cell therapy of many diseases. The aim of this study was to investigate the contribution of...
View ArticleSerum Sialic Acid Level Is Significantly Associated with Nonalcoholic Fatty...
Background/Aim. To investigate the association between serum sialic acid (SA) levels and nonalcoholic fatty liver disease (NAFLD) in a nonobese Chinese population. Methods. A cross-sectional study was...
View ArticleLiver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors...
Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis....
View ArticleEfficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic...
Objectives. To compare entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effects in chronic hepatitis B (CHB) patients with high HBV DNA. Method. 96 patients treated initially with tenofovir (TDF...
View ArticleCovered Stents versus Uncovered Stents for Unresectable Malignant Biliary...
Aim. To summarize the covered or uncovered SEMS for treatment of unresectable malignant distal biliary obstruction, comparing the stent patency, patient survival, and incidence of adverse events...
View ArticleVitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing...
Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC)...
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