Curcumin Decreased Oxidative Stress, Inhibited NF-B Activation, and Improved...
To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with...
View ArticleImmunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV...
No specific treatment can reverse the liver injury in cirrhosis. This study aims to characterize immune status and correlations between cirrhosis induced by HBV and HCV. Phenotypes of peripheral blood...
View ArticleSparse Logistic Regression for Diagnosis of Liver Fibrosis in Rat by Using...
The objective of the present study is to find out the quantitative relationship between progression of liver fibrosis and the levels of certain serum markers using mathematic model. We provide the...
View ArticleAttenuating Effect of Ginkgo biloba Leaves Extract on Liver Fibrosis Induced...
The purpose of this study is to investigate the effect of Ginkgo biloba leaves extract on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were...
View ArticleGecko Crude Peptides Induce Apoptosis in Human Liver Carcinoma Cells In Vitro...
Aim. To investigate the anti-tumor effects and mechanisms of gecko crude peptides (GCPs) in vitro and in vivo. Methods. 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay was...
View ArticleInhibitory Effects of the Attenuated Salmonella typhimurium Containing the...
To observe the inhibitory effects of an attenuated S. typhimurium strain carrying IL-2 gene (TPI) on hepatoma cell line (HepG2) and transplanted tumors in mice. TPI, TPG (an attenuated S. typhimurium...
View ArticleThe Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role...
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers worldwide. HCC is an example of inflammation-related cancer and represents a paradigm of the relation occurring...
View Article2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in...
Consumption of isoflavones may prevent adiposity, hepatic steatosis, and dyslipidaemia. However, studies in the area are few and primarily with genistein. This study investigated the effects of...
View ArticleNoninvasive Measurement of Murine Hepatic Acetyl-CoA 13C-Enrichment Following...
The 13C-isotopomer enrichment of hepatic cytosolic acetyl-CoA of overnight-fed mice whose drinking water was supplemented with [U-13C]fructose, and [1-13C]glucose and p-amino benzoic acid (PABA) was...
View ArticleHepatoprotective and Antioxidant Effects of Saponarin, Isolated from...
The hepatoprotective potential of saponarin, isolated from Gypsophila trichotoma, was evaluated in vitro/in vivo using a hepatotoxicity model of paracetamol-induced liver injury. In freshly isolated...
View ArticleCirrhosis and Rapid Virological Response to Peginterferon Plus Ribavirin...
Background. The rs12979860 CC genotype of the interleukin 28B (IL28B) polymorphism is associated with high rates of sustained virological response (SVR) to peginterferon (PegIFN) and ribavirin (Rbv) in...
View ArticleMetabolic Factors and Chronic Hepatitis C: A Complex Interplay
In the last years, several lines of evidence showed how metabolic factors may influence the natural history of patients with chronic hepatitis C. Chronic HCV infection is able to perturb the metabolic...
View ArticleUrsodeoxycholic Acid Improves Bilirubin but Not Albumin in Primary Biliary...
Background/Aim. In randomised controlled trials (RCTs) of ursodeoxycholic acid (UDCA), although serum bilirubin is frequently reduced, its effect on disease progression and mortality is unclear. As...
View ArticleRole of the Plasma Membrane Transporter of Organic Cations OCT1 and Its...
Changes in the uptake of many drugs by the target cells may dramatically affect the pharmacological response. Thus, downregulation of SLC22A1, which encodes the organic cation transporter type 1...
View ArticleSpleen Stiffness Correlates with the Presence of Ascites but Not Esophageal...
Although spleen stiffness has recently been identified as potential surrogate marker for portal hypertension, the relationship between spleen stiffness and portal hypertension has not been fully...
View ArticleISG15 Inhibits IFN-α-Resistant Liver Cancer Cell Growth
Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide. Interferon-α (IFN-α) has been widely used in the treatment of HCC, but patients eventually develop resistance. ISG15...
View ArticleLPS Increases MUC5AC by TACE/TGF-α/EGFR Pathway in Human Intrahepatic Biliary...
Background. Mucin 5AC (MUC5AC) overproduction plays important roles in stone formation and recurrence of hepatolithiasis. We aim to investigate the involved mechanism and the potential target to block...
View ArticleThe Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in...
Background. The impact of hepatic steatosis on outcome following hepatic ischemia-reperfusion injury (IRI) remains controversial with conflicting clinical results. A number of experimental studies have...
View ArticleGreen Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis...
The beneficial effects of green tea polyphenols (GTP) against metabolic syndrome and type 2 diabetes by suppressing appetite and nutrient absorption have been well reported. However the direct effects...
View ArticleEffect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total...
To gain insight into the hepatohistological alterations in noninjured rat liver, Nerium oleander (N.O.) leaves extract was injected intramuscularly to induce an acute phase reaction (APR)....
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