Evidence for a “Pathogenic Triumvirate” in Congenital Hepatic Fibrosis in...
Autosomal recessive polycystic kidney disease (ARPKD) is a severe monogenic disorder that occurs due to mutations in the PKHD1 gene. Congenital hepatic fibrosis (CHF) associated with ARPKD is...
View ArticlePathological Predictors of Shunt Stenosis and Hepatic Encephalopathy after...
Background. Transjugular intrahepatic portosystemic shunt (TIPS) is an artificial channel from the portal vein to the hepatic vein or vena cava for controlling portal vein hypertension. The major...
View ArticleiTRAQ-Based Proteomics Identification of Serum Biomarkers of Two Chronic...
Background. Chronic infection with hepatitis B virus (HBV) is a leading cause of cirrhosis and hepatocellular carcinoma. By traditional Chinese medicine (TCM) pattern classification, damp heat stasis...
View ArticleHuman Endogenous Retroviruses-K (HML-2) Expression Is Correlated with...
Background. The association between human endogenous retroviruses-K (HERV-K) (HML-2) and human disease, including a variety of cancers, has been indicated. However, the function of HERV-K (HML-2) in...
View ArticleHepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular...
Hepatocellular carcinoma (HCC) is a major public health concern and one of the leading causes of tumour-related deaths worldwide. Extensive evidence endorses that HCC is a multifactorial disease...
View ArticleCoronary Computed Tomography Angiography in Combination with Coronary Artery...
Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical...
View ArticleCellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver...
The emerging field of regenerative medicine offers innovative methods of cell therapy and tissue/organ engineering as a novel approach to liver disease treatment. The ultimate scientific foundation of...
View ArticleFavorable Outcomes of Chinese HCV-Related Cirrhotic Patients with Sustained...
Few studies have conducted follow-up investigations of the clinical course in HCV-related cirrhotic patients who achieved a sustained virological response (SVR) with pegylated interferon plus ribavirin...
View ArticleStellate Cell Activation and Imbalanced Expression of TGF-β1/TGF-β3 in Acute...
Objective. To study the pathogenic feature of liver injury, activation of hepatic stellate cells, and dynamic expression of TGF-β1/TGF-β3 to reveal their role in liver injury induced by ConA. Methods....
View ArticleGallstones in Patients with Chronic Liver Diseases
With prevalence of 10–20% in adults in developed countries, gallstone disease (GSD) is one of the most prevalent and costly gastrointestinal tract disorders in the world. In addition to gallstone...
View ArticleChenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and...
Aim. To investigate the effects of HS-1200 on liver tumorigenesis and liver function in a diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC) rat model. Methods. Rats were randomly...
View ArticleFunctional Roles and Therapeutic Applications of Exosomes in Hepatocellular...
Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to...
View ArticleSECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis
Liver fibrosis is a wound-healing response to chronic liver injury such as alcoholic/nonalcoholic fatty liver disease and viral hepatitis with no FDA-approved treatments. Liver fibrosis results in a...
View ArticleA Potential of sFasL in Preventing Gland Injury in Sjogren’s Syndrome
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL...
View ArticleDiagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in...
Liver biopsy still remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH), but with limitations. There is an urgent need to develop noninvasive tests that accurately distinguish...
View ArticleA Noninvasive Score Model for Prediction of NASH in Patients with Chronic...
Aims. To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD. Objective and Methods. 65 CHB patients with NAFLD were divided into NASH group (34 patients) and...
View ArticleIncreased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible...
Aim. ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis. This study aimed to find whether HBV infection altered ERp57 expression and...
View ArticleCarvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile...
Background. The sympathetic nervous system (SNS) is responsible for hepatic stellate cells (HSCs) activation and the accumulation of collagen that occurs in hepatic fibrogenesis. Carvedilol has been...
View ArticleNew Insights into the Epigenetics of Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate. This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and...
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