Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by...
Background. Excessive acetaminophen (APAP) use can lead to acute liver injury (ALI) by inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with the peroxisome...
View ArticleGRWR Correlates with the Metabolism of Tacrolimus after Pediatric Living...
Objectives. Tacrolimus is characterized by high pharmacokinetic variability in combination with a narrow therapeutic range. However, influence of donor CYP3A5 genotype and graft-to-recipient body...
View ArticleOlmesartan Improves Hepatic Sinusoidal Remodeling in Mice with Carbon...
Aim. In mice with liver fibrosis produced by carbon tetrachloride (CCl4), the effects of olmesartan on intrahepatic angiogenesis and sinusoidal remodeling will be evaluated. Methods. By injecting CCl4...
View ArticleAdverse Effects of Bisphenol A on the Liver and Its Underlying Mechanisms:...
BPA is a known endocrine-disrupting agent that is capable of binding to the estrogen receptor and has exhibited adverse effects in many laboratory animal and in vitro studies. Moreover, it also been...
View ArticleAntiviral Therapy for Prevention of Perinatal Hepatitis B Virus Transmission...
Background: Currently, there are few studies on the effect of prophylactic anti-hepatitis B virus (HBV) therapy (AVT) for mother-to-child transmission during pregnancy on postpartum hepatitis flare...
View ArticleIntervention of Shugan Xiaozhi Decoction on Nonalcoholic Fatty Liver Disease...
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with an increasing incidence rate but few therapies. Shugan Xiaozhi decoction (SX) has demonstrated beneficial effects in treating...
View ArticleSilencing the ADAM9 Gene through CRISPR/Cas9 Protects Mice from...
Alcoholic liver injury is a major global public health concern at present. The ADAM9 gene plays a crucial role in the occurrence and development of various liver diseases, but its role in acute...
View ArticleDiagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A...
Background. Serum chitinase-3-like protein 1 (CHI3L1) is a promising marker for diagnosing liver fibrosis. This meta-analysis was carried out to assess the diagnostic performance of serum CHI3L1 for...
View ArticleIdentification of MAD2L1 as a Potential Biomarker in Hepatocellular Carcinoma...
Background. Hepatocellular carcinoma (HCC) is widely acknowledged as a malignant tumor with rapid progression, high recurrence rate, and poor prognosis. At present, there is a paucity of reliable...
View ArticleMultiple Intestinal Bacteria Associated with the Better Protective Effect of...
Bifidobacterium pseudocatenulatum LI09 could protect rats from D-galactosamine- (D-GalN-) induced liver injury. However, individual difference in the protective effects of LI09 on the liver injury...
View ArticleEffects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules...
The aim of the present study was to investigate the effects and mechanism of oxymatrine (OMT) combined with compound yinchen granules (CYG) on the apoptosis of hepatocytes through the Akt/FoxO3a/Bim...
View ArticleTreg/Th17 Cell Balance in Patients with Hepatitis B Virus-Related...
Background. T-helper 17 (Th17) and CD4+CD25+ T-regulatory (Treg) cells play important roles in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This study is...
View ArticleLycopene Ameliorates Liver Inflammation and Redox Status in Mice Exposed to...
Cigarette smoke (CS) is the major cause of preventable death worldwide, and it can also cause damage to extrapulmonary organs, such as the liver, mainly due the generation of reactive oxygen species...
View ArticleEffects of Preoperative Oral Carbohydrate on Cirrhotic Patients under...
Preoperative fasting causes significant perioperative discomfort in patients. Preoperative oral carbohydrate (POC) is an important element of the enhanced recovery after surgery protocol, but its...
View ArticlePicroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury...
Picroside II is an important ingredient agent in Traditional Chinese medicine and hoped to reduce hepatocellular injury caused by severe acute pancreatitis (SAP). An SAP-induced hepatocellular injury...
View ArticleAssociation of Low High-Density Lipoprotein Cholesterol Levels with Poor...
Background. Lipid levels become decreased in cirrhotic patients and are correlated with disease severity. In the present study, we investigated the impact of serum high-density lipoprotein cholesterol...
View ArticleAntitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular...
Background and Aim. Although a strong antitumor effect of lenvatinib has been noted for patients with unresectable hepatocellular carcinoma (HCC), its efficacy requires improvement. It is imperative to...
View ArticleLiver Enzymes and Their Association with Some Cardiometabolic Diseases:...
Objective. According to reports, liver enzymes might play a role in the incidence and development of cardiometabolic diseases such as metabolic syndrome (MetS), hypertension (HTN), and cardiovascular...
View ArticleDownregulation of snoRNA SNORA52 and Its Clinical Significance in...
Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic...
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